Pipeweed is a comestible that, when ingested, lowers a creature's hostility to zero. It also makes them extremely hungry. Even when attacked, enemies will often not defend themselves while under its effects. Enemies of a gas Composition Type are immune to pipeweed's effects.
It is difficult to get most creatures to ingest pipeweed, but ingesting it near them will cause a "contact buzz".
Pipeweed can only be purchased from the dealer, J.R.R. Tokin. He is more likely to sell it to you if you have committed a major crime, such as robbing the bank, thus proving that you're not an undercover police officer.